- Similar to a Cannon Turret, the Annihilator's Cannon will briefly flash red before it fires.
- Without support, the slow rotation and reload of the Annihilator can make it an easy target for Helldivers at close range. It is recommended that Helldivers approach the Tank facing away from its coaxial Fusion Repeater.
- The back of the Annihilator's Cannon has a large vent that can be damaged by medium armor-piercing Support Weapons such as the AC-8 Autocannon.